The Louisiana Weekly was founded by New Orleans African American community leaders O.C.W. Taylor and C.C. Dejoie Sr. in 1925. Taylor was a former teacher of the New Orleans Public Schools system and C.C. Dejoie was President of the Unity Industrial Life Insurance Company. The Weekly's original headquarters was at 303 Pythian Temple Building. Dejoie used his business entrepreneurial skills and persuaded insurance agents to sell subscriptions and copies of the publication and use their contacts in the community to relay stories and issues of importance to the African American community. The first two issues of the newspaper appeared under the title of The New Orleans Herald. By October 17, 1925, the newspaper had 4,500 subscribers, which its founders called a "record in Negro journalism."