Lisle is a village in DuPage County, Illinois, United States. The population was 22,390 at the 2010 census, and in 2019 the population was recorded to be 23,270. It is part of the Chicago metropolitan area and the Illinois Technology and Research Corridor. It is also the headquarters of the Nuclear Regulatory Commission Region III.
In July 2007, Lisle was ranked No. 20 in Money magazine's list of "100 Best Places to Live" and No. 17 on their 2009 list of the "Best Places for the Rich and Single."