Niccolò De Simone, also called Nicolò Fiammingo, Lo Zet, or Lopet, was a Flemish painter, active during 1636–1654 in Naples, Italy. He was born in Liege. His style suggests he was in the circle or influenced by Massimo Stanzione, Bernardo Cavallino, and Mattia Preti. Bernardo de' Dominici claims he was also painting in Spain and Portugal. A painting attributed to Simone is found in the John and Mable Ringling Museum of Art.