George Jacobs Sr. was an English colonist in the Massachusetts Bay Colony who was accused of witchcraft in 1692 during the Salem witch trials in Salem Village, Massachusetts. He was convicted and hanged on August 19, 1692. His son, George Jr., was also accused but evaded arrest. Jacobs' accusers included his daughter-in-law and granddaughter, Margaret.
Jacobs was believed to be the George Jacob baptized 13 February 1608/09 at St. Dunstan in the West, London, son of barber-surgeon George Jacob and wife Priscilla of Bishop's Stortford, Hertfordshire.