Vaison-la-Romaine is a town in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.
Vaison-la-Romaine is famous for its rich Roman ruins and mediaeval town and cathedral. It is also unusual in the way the antique, mediaeval and modern towns spanning 2,000 years of history lie close together.
The old town is split into two parts: the "upper city" or Colline du Château on a hill on one side of the Ouvèze, and on the opposite bank, the "lower city" centred on the Colline de la Villasse.
With four theatres and numerous exhibitions and galleries, Vaison-la-Romaine is also renowned for its art scene. Many writers, painters and actors live in the area.