Guardiagrele is a town and comune in the province of Chieti, part of the Abruzzo region of central Italy. It is in the foothills of the Maiella mountain at an elevation of around 576 metres. Its population numbers about 10,000.
Commenting on the views of the mountains and valleys of the Maiella visible from some points in the town, the poet Gabriele d'Annunzio nicknamed Guardiagrele la terrazza d'Abruzzo.
Guardiagrele is the seat of the Maiella National Park, and was part of the club I Borghi più belli d'Italia.