Gautamiputra Satakarni Brahmi: 𑀕𑁄𑀢𑀫𑀺𑀧𑀼𑀢 𑀲𑀸𑀢𑀓𑀡𑀺, Gotamiputa Sātakaṇi, IAST: Gautamīputra Śatakarṇi was a ruler of the Satavahana Empire in present-day Deccan region of India. He was mentioned as the important and greatest ruler of Satavahana Dynasty. He ruled in the 1st or 2nd century CE, although his exact period is uncertain. His reign is dated variously: 86-110 CE, c. 103-127 CE, 106-130 CE, or more recently and specifically ca. 60-85 CE.
The information available about Gautamiputra Satakarni comes from his coins, the Satavahana inscriptions, and the royal genealogies in the various Puranas. The best known of these is the Nashik prashasti inscription of his mother Gautami Balashri, which credits him with extensive military conquests. Historical evidence suggests that Gautamiputra revived the Satavahana power after a decline caused by Saka invasions.