Hedwig of Munsterberg-Oels was born Duchess of Münsterberg and Oleśnica and Countess of Kladsko and by marriage Margravine of Brandenburg-Ansbach-Kulmbach.
Hedwig was a daughter of Duke Charles I of Münsterberg-Oels, who was a grandson of the King George of Bohemia. Her mother was Anna of Sagan, a daughter of John II, the last Duke of Żagań.
On 9 January 1525 Hedwig married George, Margrave of Brandenburg-Ansbach-Kulmbach. She was George's second wife. The marriage produced two daughters:
Anna Maria married in 1544 Duke Christoph of Württemberg
Sabina married in 1548 Elector Johann Georg of Brandenburg
Hedwig died in Legnica, where she was buried.