Zafferana Etnea is a comune in the Metropolitan City of Catania in the Italian region Sicily, located about 160 kilometres southeast of Palermo and about 20 kilometres north of Catania.
The municipality of Zafferana Etnea contains the frazioni Fleri, Pisano, Petrulli; Sarro-Civita, Passopomo, Airone-Emmaus, Poggiofelice, and Caselle.
Zafferana Etnea borders the following municipalities: Aci Sant'Antonio, Acireale, Adrano, Belpasso, Biancavilla, Bronte, Castiglione di Sicilia, Giarre, Maletto, Milo, Nicolosi, Pedara, Randazzo, Sant'Alfio, Santa Venerina, Trecastagni, Viagrande.