Oranienburger Straße is a street in central Berlin. It is located in the borough of Mitte, north of the River Spree, and runs south-east from Friedrichstraße to Hackescher Markt.
The street is popular with tourists and Berliners for its nightlife with numerous restaurants and bars. Formerly a centre of Jewish life in Berlin, the street contains the restored New Synagogue. Another tourist landmark was the Kunsthaus Tacheles, an alternative art center and night club. After it was depopulated of its people, its largely middle class Jewish population having been murdered, a then abandoned Oranienburger Straße became popular with anarchists, young artists and was also known for its street prostitution, which is legal in Germany.
There are also two lesser known streets named "Oranienburger Straße" in Berlin, in Reinickendorf and in Lichtenrade. The name is derived from the nearby town of Oranienburg.