Saint-Guilhem-le-Désert is a commune in the Hérault department in the Occitanie region in southern France. Situated in the narrow valley of the Gellone river where it meets the steep-sided gorge of the Hérault River, Saint-Guilhem-le-Désert is essentially a medieval village located on the Chemin de St-Jacques pilgrim route to Santiago de Compostella.