This impressive panel from the city's church of San Franceso, representing the Madonna of Mercy and Saints Sebastian and Bernardino from Siena, figures that the artist Luca Signorelli outlined with statuesque robustness probably in the same period of the frescoes in the Chapel of San Brizio in Orvieto, his indiscussed masterpiece. Some lower quality of the painting could suggest the presence of some pupil in the workshop, even the bad conservation couldn't help a correct reading; however here can be traced all the influencing style on Signorelli: the drawing from Florentine tradition, the volumetrical studies of Verrocchio, Ghirlandaio, Francesco di Giorgio, and of course the Roman experience.