The panel is the centrepiece of a larger poliptych from the parish Church of Santi Leonardo and Cristoforo in Monticchiello, near Pienza. The other elements are probably: a Saint Agathe now at Le Mans Museum, and the panels with Saint Leonard, Saint Catherine and Saint Margaret at the Florentine Horne Museum. It is a masterpiece by Pietro Loreazetti, astonishing for the extraordinary vivacity of the interaction between mother and son and the useful lessons of his brother, Ambrogio; Simone Martini in the refined style; of Giovanni Pisano in expressing pathos and eventually of Giotto.