This painting belongs to a set of four panels dedicated to the life and legend of Saint Roch that made up part of the altar-piece of the old Shrine of São Roque, constructed in 1505. (I. Birth and adolescence of Saint Roch, II. The Healing of the Cardinal, III. Stay in Piacenza and retreat in the forest; IV. Imprisonment and beatific death of Saint Roch). These four paintings stand out for their narrative capacity managed by means of duplication of scenes within the same panel. In each of the panels two distinct episodes of the life of the saint are represented: in the foreground, chronologically the first episode; in the background, the second episode, inserted or seen through a window. In this second panel the episode of Saint Roch’s miraculous healing of the English cardinal is represented in the foreground. The saint, standing next to the bed of the sick, traces the sign of the cross on his forehead. At the foot of the cardinal’s bed, one can observe the ecclesiastical clothes, which identify him, and a cup and two jars placed on a wooden bench. Two young men, with their arms raised and kneeling at the foot of the cardinal's bed, watch the miraculous cure. On the wall, a small painting with the representation of Calvary.