Seghers, a Flemish artist who specialised in painting flowers, often combined his flowers with a stone statue. This bust is of King-stadholder Willem III, the stadholder of Holland who was also the king of England. The branches of orange blossom and the orange lilies refer to his family name: of Orange.
The painting was probably a gift from Seghers to Constantijn Huygens, the secretary of the stadholder. Until the mid-nineteenth century, it hung in his home, close to the Mauritshuis.