Ludovisi was entrusted with one of the most significant sculptural projects for the Lisbon chapel. Between 1743 and 1744, he produced one of the two marble reliefs for the vaulting – that on the Epistle side, depicting "S. João Baptista Pregando no Deserto" (St. John the Baptist Preaching in the Desert) -, two putti and two cherubim heads (1744), that flank and crown the frame of the relief and a further eight cherubim heads (1744) enhancing the coffered vaulting. The quality of the modelling is beyond question, owing to the expressiveness of both physiognomy and gesture, which characterizes Ludovisi’s sculptures.