The main umami substances are glutamate, inosinate and guanylate, and it has been scientifically proven that umami is sensed far more strongly when these are present not individually, but when glutamate is combined with inosinate or guanylate. This is referred to as umami synergy. Umami was found to be most powerful with a glutamate to inosinate ratio of exactly 1:1. This proportion was deemed 7 to 8 times the intensity of tasting either glutamate or inosinate in isolation.