Brežice is a town in eastern Slovenia in the Lower Sava Valley, near the Croatian border. It is the seat of the Municipality of Brežice. The area was traditionally divided between Lower Styria and Lower Carniola. The whole municipality is now included in the Lower Sava Statistical Region.
Brežice prides itself on a rich historical and cultural heritage. The Lower Sava Valley Museum, housed in Brežice Castle, contains archaeological and ethnological exhibits, exhibits on the Croatian and Slovenian peasant revolt, and a modern history collection. It is one of the largest regional museums in the country. A more recent landmark addition to the town is its water tower, as well as the double arches of the 527 m long iron bridge, which spans the Sava and Krka rivers.