Bizeljsko is a settlement in the Municipality of Brežice in eastern Slovenia, close to the border with Croatia. It lies on the right bank of the Sotla River and in terms of its territory is the largest settlement in the Municipality of Brežice. The area is part of the traditional region of Styria. It is now included in the Lower Sava Statistical Region. It includes the hamlets of Bošt, Nimnik, Gradišče, Župjek, Spodnja Sušica, Zgornja Sušica, Janežičeva Gorca, Vrhovnica, and Vitna Vas.