Casas Grandes Municipality is located in the northern Mexican state of Chihuahua. The municipal seat is the town of Casas Grandes, Chihuahua.
The pre-Columbian archaeological zone Casas Grandes and its central site, after which the municipality is named, is located within the municipality's territory. The site of Casas Grandes, alternatively known as Paquimé, is one of the most significant pre-Columbian cultural and archaeological sites in the region of northwestern Mexico and the southwestern United States known in some archaeological contexts as the Oasisamerica culture area.