Domenico Veneziano was an Italian painter of the early Renaissance, active mostly in Perugia and Tuscany.
Little is known of his birth, though he is thought to have been born in Venice, hence his last name. He then moved to Florence in 1422–23 as a boy, to become a pupil of Gentile da Fabriano. He is said to have worked with Pisanello in Rome around 1423–1430. His work was influenced by the style of Benozzo Gozzoli.
In a letter from him to Piero di Cosimo de' Medici, dated from Perugia in 1438, where he likewise resided for many years, he mentions his long connection with the fortunes of the Medici family, and begs to be allowed to paint an altarpiece for the head of that house. He was a contemporary with Fra Angelico and Fra Filippo Lippi, since those two artists and himself are known to have valued the frescoes of Buonfigli at Perugia. Between 1439 and 1441 he painted a masterpiece of the Adoration of the Magi.
Another masterpiece is considered to be the Santa Lucia de' Magnoli Altarpiece, originally in Santa Lucia dei Magnoli, Florence and now in the Uffizi.