Juchitán de Zaragoza is an indigenous town in the southeast of the Mexican state of Oaxaca. It is part of the Juchitán District in the west of the Istmo de Tehuantepec region. With a 2005 census population of 74,714 inhabitants, it is the fourth-largest city in the state. The majority of the indigenous inhabitants are Zapotecs and Huaves. The town also serves as the municipal seat for the surrounding municipality, with which it shares a name. The municipality has an area of 414.64 km² and a population of 85,869, the state's third-largest in population.
It is located 26 km northeast of the city of Tehuantepec. Its Palacio Municipal dates back to the middle of the 19th century and perhaps is the widest "palace" in Mexico with 31 arches in its front portal. Its main church is the Parroquia de San Vicente Ferrer which dates from the 17th century. To the west of the Palacio is a large market where local products can be seen and a local variant of the Zapotec language can be heard.