Ladysmith is a city in the Uthukela District of KwaZulu-Natal, South Africa. It lies 230 kilometres north-west of Durban and 365 kilometres south-east of Johannesburg. Important industries in the area include food processing, textiles, and tyre production.
Ladysmith is the seat for both the Alfred Duma Local Municipality and Uthukela District Municipality.
In 1900, the unincorporated town of Oyster Harbour on the east coast of Vancouver Island, British Columbia, Canada, was renamed Ladysmith by James Dunsmuir, in honour of the British lifting the siege of Ladysmith in South Africa during the Second Boer War.