Term generally used for periods that hark back to the culture of Classical antiquity. Though it has applications elsewhere, it is most often used to refer to that era in Europe, beginning approximately in the 14th century, in which a new style in painting, sculpture and architecture was forged in succession to that of Gothic and in which, in a broader cultural sense, the transition from the Middle Ages to the modern age was made. This period culminated in the High Renaissance, a brief phenomenon confined essentially to Italy in about the first two decades of the 16th century and supremely embodied in some of the work of that time by Leonardo da Vinci, Michelangelo and Raphael. Following this came that phase of the late Renaissance called 'Mannerism'.