Blyde River Canyon Nature Reserve is situated in the Drakensberg escarpment region of eastern Mpumalanga, South Africa. The reserve protects the Blyde River Canyon, including sections of the Ohrigstad and Blyde Rivers and the geological formations around Bourke's Luck Potholes, where the Treur River tumbles into the Blyde below. Southwards of the canyon, the reserve follows the escarpment, to include the Devil's and God's Window, the latter a popular viewpoint to the lowveld at the reserve's southern extremity.
The Mogologolo, Mariepskop and Hebronberg massifs are partially included in the reserve. Elevation varies from 560 m to 1,944 m above sea level. Its resort areas are F.H. Odendaal and Swadeni, the latter only accessible from Limpopo province. The area of approximately 29,000 hectares is administered by the Mpumalanga Parks Board.