Santana de Parnaíba is a city and municipality in the state of São Paulo in Brazil. It is part of the Metropolitan Region of São Paulo. The population is 142,301 in an area of 179.95 km². It was founded in 1625 near the Tietê River by Susana Dias, an important Bandeirante wife. It was the birthplace of prominent Bandeirante Domingos Jorge Velho.
The word Parnaíba means rocky river.
The municipality contains and administers the 367-hectare Tamboré Biological Reserve, a strictly protected conservation unit.