Columbus is a city in and the county seat of Lowndes County, on the eastern border of Mississippi, United States, located primarily east, but also north and northeast of the Tombigbee River, which is also part of the Tennessee-Tombigbee Waterway. It is approximately 146 miles northeast of Jackson, 92 miles north of Meridian, 63 miles south of Tupelo, 60 miles northwest of Tuscaloosa, Alabama, and 120 miles west of Birmingham, Alabama.
The population was 25,944 at the 2000 census and 23,640 in 2010. The population in 2019 was estimated to be 23,573. Columbus is the principal city of the Columbus Micropolitan Statistical Area, which is part of the larger Columbus-West Point Combined Statistical Area. Columbus is also part of the area of Mississippi called The Golden Triangle, consisting of Columbus, West Point and Starkville, in the counties of Lowndes, Clay and Oktibbeha.