Molo is one of the seven districts of Iloilo City. Molo was a separate municipality before it was incorporated into the municipality of Iloilo by virtue of Act No. 719 of 1903. Molo was originally the parián of Iloilo, which is the area that the Chinese residents of Iloilo lived in.
Several known families that came from Molo include - the Locsin, Lacson, Sayson, Pison, Layson, Yusay, Sayson, among others, who are descended from Chinese immigrants who hispanized, adopted Roman Catholicism and settled in Molo.
Molo is home to St. Anne Parish Church, more commonly known as Molo Church, which lies in front of the Molo Plaza. The national high school of the city, Iloilo City National High School, is located in Molo. The Department of Social Welfare and Development and Bureau of Internal Revenue are among the government agencies with regional offices in Molo.
The Philippines' national hero, José Rizal, visited Molo Church on his way to Manila from exile in Dapitan. He exclaimed "La iglesia bonita!" as he saw the church, acknowledging its beauty.