San Daniele del Friuli is a comune in the Province of Udine in the Italian region Friuli-Venezia Giulia, located about 80 kilometres northwest of Trieste and about 20 kilometres northwest of Udine.
San Daniele del Friuli borders these municipalities: Dignano, Forgaria nel Friuli, Majano, Osoppo, Pinzano al Tagliamento, Ragogna, Rive d'Arcano, and Spilimbergo.
San Daniele is best known as the production center of the San Daniele prosciutto The prosciutto is celebrated every summer at the end of June during the Aria di Festa.