Museu Catavento
In partnership with SBIm, the Brazilian Society of Immunizations.
A world without vaccines
Imagine a world where vaccines didn't exist. Diseases like measles, polio and flu would be a constant threat. Many people, especially children, would die from diseases that can be prevented today.
Without effective treatment, epidemics would be frequent, and society would live in fear of fatal diseases spreading easily.
Vacinas - Peste bubônica by Getty Images / BBC News BrasilMuseu Catavento
Diseases have always been a scourge for humanity.
The bubonic plague, for example, killed 1/3 of the people in Europe between 1346 and 1356. The discovery of vaccines is an extraordinary feat of science and saves millions of lives.
Vaccines protect us all, preventing dangerous diseases and saving millions of lives. With vaccines, we can live safer and healthier lives, ensuring that diseases don't spread and protecting the health of the whole community.
How did vaccines come about?
First immunizers and the first vaccine
Vacinas - Antiguidade (2023-11-01) by Marília NavickaiteMuseu Catavento
ANTIQUITY
Ancient civilizations in China, India and Turkey already inoculated pus, or smallpox scab powder, into healthy people to develop resistance to the disease.
1717
Mary Montagu, British writer and socialite, after learning about the method in Turkey, began promoting inoculations in England in 1717. She herself had her children successfully immunized and her letters describing the procedures promoted the idea in England.
1976
Edward Jenner developed the first smallpox vaccine. In 1976, he observed that cow milkers contracted cowpox but appeared to be immune to human smallpox.
Jenner then carried out an experiment: He collected material from a smallpox lesion from a milking machine and inoculated it into a healthy 8-year-old boy.
After infection, the child developed mild smallpox symptoms, gaining immunity.
The term “vaccine” derives from the Latin word “vacca”, which means cow, in reference to the origin of the immunizer. The discovery paved the way for other vaccines, revolutionizing preventive medicine.
Louis Pasteur and the development of the science that saves millions of lives.
LOUIS PASTEUR
Born in 1822 in France, Louis Pasteur was the scientist who shaped modern microbiology.
CONTRIBUTIONS:
GERM THEORY
He demonstrated that infectious diseases are caused by microscopic organisms. His discovery led to advances in sterilization, hygiene and vaccination.
PASTEURIZATION
Initially used in the dairy industry to prevent disease, it is now a global practice to increase food safety and shelf life.
IMPORTANT VACCINES
He created vaccines for diseases such as rabies and fowl cholera.
SCIENCE IS POWER
Pasteur's work in understanding diseases highlighted the importance of scientific research and the transformative power of science in improving humanity's quality of life.
With the advancement of science, today vaccines are developed and manufactured in high-technology laboratories.
Vaccines began to be developed around the year 1800.
World population in 1800: 1 billion
World population today: 8 billion
Extraordinary growth with the help of vaccines
Vacinas - O ataque dos microrganismos (2023-11-01) by ArchimidiaMuseu Catavento
The attack of microorganisms
Viruses and bacteria have different ways of acting in the human body.
Vacinas - Painel Vírus (2023-11-01) by ArchimidiaMuseu Catavento
Virus
Made up of genetic material (DNA or RNA) surrounded by a layer of protein.
- They need the cells of other beings to multiply (intracellular parasites).
- They attach themselves to the surface of the cell, inject their genetic material and take control of it, causing the cell to produce viral copies.
- Over time, the cell breaks down and releases the viral copies into the body.
- The immune response is activated to fight the virus, which can cause symptoms such as fever, malaise, inflammation, among other rarer adverse events.
Vacinas - painel Bactérias (2023-11-01) by ArchimidiaMuseu Catavento
Bacteria
Organisms that are more complex than viruses have a membrane, cell wall and genetic material.
- Many live in harmony with us, but some can cause diseases.
- They can multiply in different parts of the body, releasing toxins or causing damage directly to cells.
-They can invade deeper tissues and cause serious systemic diseases.
-The immune system responds to the infection in an attempt to destroy the bacteria, causing symptoms such as inflammation, pus at the site of infection and others.
Let's understand it better, shall we?
Vacinas - Tipos de vacinas (2023-11-01) by ArchimidiaMuseu Catavento
Types of vaccines
Vaccines use weakened disease agents or particles of them to induce our defense system, preparing our bodies for combat if actual exposure occurs.
Vaccines can be bacterial, which prevent bacteria, or viral, which prevent viruses. Furthermore, we can classify them according to how infectious agents are present in the formula.
Attenuated vaccines
COMPOSITION: Weakened version of the virus or bacteria.
EXAMPLES: Mumps, Oral poliomyelitis (OPV), Rubella, Measles, Varicella (chicken pox), BCG.
Inactivated vaccines
COMPOSITION: Dead viruses or bacteria, whether whole or particle.
EXAMPLE: Hepatitis A, Hepatitis B, HPV, Influenza (flu) and Covid-19.
How attenuated virus vaccines work
1 - PRODUCTION
In the laboratory, the virus is weakened through various processes, such as exposure to heat and cold, repeated cultivation, or genetic engineering. After weakening the virus, it is used to produce the vaccine.
2 - APPLICATION
The vaccine enters the body through vaccination in the form of drops or injections.
3 - DEFENSE (Immune Response)
The attenuated virus does not cause the disease, but the immune system recognizes it as a threat and mounts a defense response. This includes the production of antibodies by lymphocyte cells.
4 - IMMUNIZATION
Antibodies bind to viruses and prevent them from penetrating cells.
5 - IMMUNE MEMORY
When a person comes into contact with the real virus, the immune system “remembers” the virus and activates the protection mechanisms previously developed by vaccination.
Vacinas - O futuro das vacinas (2023-11-01) by ArchimidiaMuseu Catavento
The future of vaccines
Messenger RNA (mRNA) vaccines are recent in immunization.
They send a message to the immune system to create a response against the disease.
IMPACT ON GLOBAL HEALTH
mRNA vaccines can be developed in a much faster process than vaccines using other technologies.
The Nobel Prize for Medicine in 2023 was awarded to Katalin Karikó and Drew Weissman for the discoveries that allowed the creation of mRNA vaccines, which are effective and safe against Covid-19.
FUTURE PERSPECTIVES
mRNA vaccines are not limited to Covid-19. Researchers are exploring the use of this technology for a variety of infections, including HIV/AIDS, malaria and influenza.
National Immunization Program
The National Immunization Program (PNI) was created in 1973 to guarantee the vaccination of all Brazilians.
An extraordinary effort by the federal government, states and municipalities, the PNI involves the production, acquisition, distribution and administration of vaccines throughout the national territory.
Vacinas - O ataque dos microrganismos (2023-11-01) by ArchimidiaMuseu Catavento
Fake News that kills
Unfortunately, a lot of fake news about vaccines circulates in society. They say they don't work, that they are harmful and that they even install microchips in our bodies.
Even though the safety and effectiveness of vaccines are proven by science, some people are not convinced and stop seeking vaccination.
The result is countless preventable deaths.
CONSEQUENCES
Less vaccination = More deaths
Since the emergence of vaccines, false news has been spread questioning their effectiveness. Here is an illustration from 1802, with Edward Jenner vaccinating patients against smallpox, where those vaccinated develop cow-like characteristics.
A collective pact for life
Vaccination goes beyond individual protection. Those who get vaccinated protect themselves and help protect the whole of society.
There are people who cannot receive certain vaccines at some point in their lives, whether due to age, health condition or treatment. But this does not mean that vaccination cannot protect them.
The greater the number of people vaccinated, the lower the circulation of viruses and bacteria in the environment, which makes infection more difficult. This is what we call collective immunity!
Vacinas - Como o Brasil está hoje (2023-11-01) by ArchimidiaMuseu Catavento
How Brazil is today
Brazil was once a global example of vaccination, but today it is experiencing a delicate situation. For several reasons, including the false feeling that diseases are not dangerous, Brazilians stopped getting vaccinated.
Measles, which had been eliminated from the country, has returned because of low vaccination coverage. And the same situation could repeat itself with other diseases.
We can't bring back these nightmares from the past.
GET VACCINATED
Vacinas - Seja um guardião da saúde! (2023-11-01) by ArchimidiaMuseu Catavento
Be a health guardian!
Make sure you and your family are up to date with health protection. Consult the vaccination schedules for different ages and groups.
Go to a health unit or clinic of your choice to update your vaccination schedule.
Share the importance of this care with everyone you love!
GOVERNMENT OF THE STATE OF SÃO PAULO
GOVERNOR
Tarcísio de Freitas
VICE GOVERNOR
Felício Ramuth
SECRETARY OF CULTURE, ECONOMY AND CREATIVE INDUSTRY
Marilia Marton
EXECUTIVE SECRETARY
Marcelo Assis
CHIEF OF STAFF
Daniel Rodrigues
COORDINATOR OF THE MUSEUM HERITAGE PRESERVATION UNIT
Mirian Yagui
CULTURAL AND EDUCATIONAL CATAVENTO
CHAIRMAN OF THE BOARD OF DIRECTORS
Sergio Freitas
EXECUTIVE DIRECTOR
Jacques Kann
FINANCIAL DIRECTOR
Gisele Regina da Silva
CATAVENTO TECHNICAL CENTER
CURATORSHIP, RESEARCH, TEXTS AND EXHIBITION DESIGN
Ricardo Pisanelli
Paula Ferreira
Rodrigo Silva
Maria Cecilia Bicarato
Mileny Carvalho
SBIM TECHNICAL CENTER
SCIENTIFIC CURATION, TEXTS AND EXPOGRAPHY
Renato Kfouri
Mônica Levi
ART DIRECTION
Ricardo Pisanelli
André Wissenbach
GRAPHIC DESIGN
Tissa Kimoto
Leila Schöntag
ILLUSTRATIONS
Marília Navickaite
ANIMATION
Rolnei Tavares
TECHNICAL DETAILING AND EXECUTION
Archimidia
VISUAL COMMUNICATION
Criart
VIRTUAL PROJECT
Luara Brito
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