Amphipolis is a municipality in the Serres regional unit of Greece. The seat of the municipality is Rodolivos. It was an ancient Greek polis, and later a Roman city, whose large remains can still be seen.
Amphipolis, an Athenian colony, was the seat of the battle between the Spartans and Athenians in 422 BC, and also the place where Alexander the Great prepared for campaigns leading to his invasion of Asia. Alexander's three finest admirals, Nearchus, Androsthenes and Laomedon, resided in Amphipolis, which is also the place where, after Alexander's death, his wife Roxana and their son Alexander IV were exiled and later murdered.
Excavations in and around the city have revealed important buildings, ancient walls and tombs. The finds are displayed at the archaeological museum of Amphipolis. At the nearby vast Kasta burial mound, an ancient Macedonian tomb has recently been revealed. The Lion of Amphipolis monument nearby is a popular destination for visitors.
It was located within the region of Edonis.