Petrolina is a municipality located in the southernmost point of the state of Pernambuco, in Northeast Brazil, in the valley of the São Francisco River. The population was 354,317 in 2020, and the total area is 4,756.8 km², making it the largest municipality in the state by area. The municipality is closely integrated with Juazeiro, Bahia, located on the opposite bank of the São Francisco.