The mola is an art form that is part of the traditional women's clothing of the Kuna, an indigenous people from Panama and Colombia. This mola panel is made with cotton fabric and handsewn with reverse applique. It has a red background with a multi-colored design of a human figure, squatting, with arms raised, wearing a crown or headdress. Text at top: "ISTMENOS"
"Istmenos" is probably Istmeños = natives/inhabitants of the Isthmus.