Lockwood, a known advocate of Temperance, nevertheless approved of such nerve tonics as Nervura, which contained a 17% alcoholic content. In 1886, she teamed up with homeopathic physician E. B. Rankin to form the Lockwood Improvement Syndicate, which, among other things, proposed to manufacture its own tonic based upon Rankin's ideas. How far this venture went is problematic. There are no records of incorporation, only two examples of the stock are known, and no examples of her tonic have been uncovered.