The interior of Derby Cathedral the Georgian is bright and full of natural light. There are memorials to famous Derbyshire people such as Bess of Hardwick, a notable figure of Elizabethan English society, and Florence Nightingale "The Lady with the Lamp", English social reformer and the founder of modern nursing. Extending across the width of the church is an intricate wrought-iron chancel screen made by local iron-smith Robert Bakewell.
The original parish church of All Saints in the town of Derby, in the county of Derbyshire, was demolished in 1723 after it was deemed structurally unsafe. The church was then redesigned by architect James Gibbs in a Neo-Classical design and was awarded Cathedral status in 1927.