Dame Deborah Hopton was the daughter of Robert Hatton, serjeant-at-law, and his wife Alice Dreynes Hatton of Thames Ditton in Surrey. She was born c.1627, being baptised in March of that year at the parish church there. Her first husband was Isaac Jones, Gentleman (c.1620-1647), whom she married in 1644 and by whom she had two children, Isaac and Alice. The family lived at Kingston, Surrey but held property in Bletchingley, Surrey and at Austin Friars in the City of London.