This relief is one of four produced for the ciborium (canopy) erected by Cardinal Guillaume d'Estouteville over the high altar of the church of Santa Maria Maggiore in Rome. The ciborium was taken apart in 1747 and the other three panels--Christ Blessing, The Annunciation, and Saints Peter and Paul--were set into the walls of the sacristy.
You are all set!
Your first Culture Weekly will arrive this week.