Painted around 1600 by Ippolito Scarsella known as Scarsellino, the canvas originally decorated the choir in the church of Saint Margaret. The patron saint is pictured together with St Clare and St Francis worshipping the famous Madonna of Reggio, a cult brought to Ferrara by Margherita Gonzaga, the last duchess, and which remained active even after her death and into the Devolution (1598).