Giuseppe Biraghi (1783-1843), a wealthy Milanese landowner, nominates Giuseppe Orsi, his friend, as a heir, establishing a legacy for the Ospedale Maggiore. The portrait, commissioned from the painter Andrea Appiani the Younger, the namesake nephew of the most famous artist, represents him in an environment with bare walls, almost like an anonymous hotel room and not a room in his house, but with a masterly and evocative illumination coming from the window.