Signed, dated and painted for the altar of St. Crescentius in the Duomo of Siena, this panel was flanked by lateral depictions of St. Crescentius and St. Michael the Archangel which are now lost. Removed in the mid 17th century, it was sent to the Accademia in Florence in 1822. It is one of the masterpieces of the artist's maturity and shows Christ recognized as the Redeemer by the elderly prophetess Anna and by Simeon who holds the Child in his arms. It has been in the Uffizi since 1913.