This retablo is an interesting group for the second half of the 15th century paintings. Made under the patronage of Alonso Fonseca, archbishop of Seville and member of one of the most influential families of the Kingdom of Castile, represented in the piece by its coat of arms, is the work of the painter Jorge Ingles and comes from the Monastery of Mejorada de Olmedo. It has a structure with refined Gothic traceries and openwork canopies. The distribution of the scenes matches the traditional narration sequence where the main hagiographic events of the life of Saint Jerome take place. The central scene presents him in a writing stance, surrounded by writing instruments and with the lion, his typical symbol and also bigger in size, which indicates his more important role. The four side panels tell the most important events of his life, developing the miracle of the lion to end up with his death. The retablo is supported by a bench, with the figures of Christ Man of Sorrows, the Virgin, Saint John and other saints. The piece is characterized by the naturalism and the power of expression of the characters, the small details and the hard and sharp pleats, searching for depth through the floors of the draught board and the introduction of landscape. The painting traditional conventionalisms are captured in the out of proportion architecture and the forced perspective, with a uniform light and without origin points.