The canvas painting was created in the middle of the second decade of the seventeenth century in Antwerp, where the artist settled upon his return to Italy. In fact, Rubens was one of the first foreign artist in the seventeenth century that had long, fruitful Italian experience from 1600 to 1608. In the painting, the central group derives from an ancient sculpture of the She-wolf and the twins next to the Tiber River. The artist saw and drew this sculpture group in the Vatican
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