This bearded cardinal once stood at the left side of a small altarpiece that Crivelli painted for a side chapel in the church of San Domenico, in Ascoli Piceno in the Italian Marche. This is Saint Jerome, one of the Fathers of the Church and a favourite saint of the Dominican Order as a defender of the Catholic faith against heresy.
He is lost in contemplation, gazing down at the small brick church he holds in his left hand. In his right hand he holds a bound book of the Bible, which he had translated into Latin; golden rays emanating from the church’s door and window stand for the light his works cast on Church doctrine. At his feet, a tame lion sits on the edge of his robes, gazing up in trusting expectation and raising its paw, which is pierced by a long thorn; Jerome was supposed to have removed it.