Saint Jerome is shown in his penitential retreat in the Syrian wilderness, where he retired about 374-6. He studies the Bible, which he translated into Latin from the original Greek and Hebrew around 400 AD, and is accompanied by the lion from whose paw, according to legend, he drew out a thorn. His cave is in the wilderness, but a walled city like those in the mainland territories of Venice can be seen in the distance.
This painting has sometimes been regarded as by a follower of Bellini. It is known in other versions.