This panel comes from stained-glass window V25 of Milan Duomo, offered by the College of Apothecaries (the current Pharmacists) in honour of Saint John of Damascus, a leading figure in the history of Byzantine theology, as well as a distinguished doctor in the history of the universal Church and patron saint of the guild. Living in the 7th century and a native of Damascus, during the reign of Emperor Leo III the Isaurian, Saint John was unjustly slandered by means of a false letter. Saint John was punished with the severing of his right hand, which was later reattached by the miraculous intervention of the Madonna. He is the patron saint of painters, the disabled (those missing limbs), and pharmacists. The original stained glass window, made by Niccolò da Varallo between 1479 and 1489, has been subjected over time to some important restorations, one of which was carried out by Pietro da Valate, followed by a more substantial restoration in the 19th century by Pompeo Bertini. This panel depicting Saint John of Damascus at the Market, according to academics, was added by Bertini workshop to the already existing episodes, as the panel depicting Saint John in his Study, attributable to this last period. There is no evidence of either in hagiograpic sources.