In her left hand, Saint Lucy holds a martyr’s palm, signifying the victory of spirit over flesh, as well as a single eye on a rod. This latter attribute refers to a legend about the saint, which told of how she plucked out her eyes because their beauty had attracted an unwelcome suitor, but God then restored them as a reward for her virtue and courage. Lucy consequently became a patron saint of sufferers from eye disease.
This work was probably painted for the church of San Francesco in Montagnana, near Padua. The specific location was the former Abriani Chapel, so the figure of the kneeling donor, represented in profile in the immediate foreground, almost certainly represents a member of the Abriani family. It is likely that the original dedication of the chapel was to Saint Lucy and that the painting served as its altarpiece.
The disjunction of scale between the saint and the donor can be interpreted as a deliberate means to express differing degrees of reality, contrasting the ideal, divine nature of the saint with the humble supplicant living in the here and now. Indeed, the difference of scale is complemented by a contrast in the pictorial handling between the two figures, with the draperies of the saint executed broadly and freely, and the head of the donor painted much more minutely.