The iconography of the fragments of this altarpiece allows us to identify its origin and estimate its age. In the first one, the saints indicate their origin, since they were Roman martyrs who died in the city of Calahorra, on the border between Navarre, Aragon and Castile, where devotion was widespread.
The plague that battered Aragon in 1497 and 1507 made the veneration of a patron saint that cured diseases popular in that zone: Saint Roch. According to the legend, he fell ill with the plague and was cured by a dog named Melampo, who appears with him on the altarpiece.