Located at 44 Vittorino da Feltre, the Santo Spirito displays a beautiful façade that is reminiscent of Alberti's style. It was rebuilt in 1418 on the site of an even older place of worship. It was then rebuilt around 1534. Dating back to the early 16th century, the nave is unique, featuring a frescoed frieze of the faces of Franciscan saints. The much-vaunted humanist, Vittorino da Feltre (1373-1446) who taught at the Court of the Gonzagas at their groundbreaking humanist school, Casa Giocosa, or "Ca' Zoiosa", is buried in the church.