The panel is part of a group that also included a "St. Catherine", today at the Poldi Pezzoli Museum in Milan. It was probably a polyptych with two levels, with a "St. Jerome" occupying one of the lower compartments and the second panel placed on the second level.
We do not have much information about the group because no other fragments are known.
This work preceded Bergognone's acquisition of an entirely sixteenth-century language, which would characterise his work from the mid-1520s.