The Charlton–King–Vandam Historic District is a small historic district in Lower Manhattan, New York City. Designated by the New York City Landmarks Preservation Commission in 1966, the district contains "the city's largest concentration of row houses in the Federal style, as well as a significant concentration of Greek Revival houses." It is sometimes included as part of the South Village or Hudson Square, though it is historically distinct from both neighborhoods.
The district includes parts, but not all, of Charlton, King and Vandam Streets between the Avenue of the Americas and Varick Street, as well as the block bounded by King, MacDougal and Houston Streets and Sixth Avenue. In its designation report, the NYCLPC emphasized that this area was not a modern creation but had once been part of a larger "distinct and separate neighborhood" that was generally developed between 1820 and 1829 and originally extended from the Hudson River to MacDougal Street, and from Vandam Street to King Street.
In 1973, the district was added to the National Register of Historic Places.